Current status

In January 2021, the below number of individuals have been recruited in Swedegene. DNA and clinical data collection for these are completed.

ADR type Number
Angioedema 530
Anaphylaxis 134
Urticaria 185
Other allergic reactions 112
Cough related to ACE-inhibitors 150
Osteonecrosis and atypical fractures due to bisphosphonates 122
Phototoxic reactions (mainly due to topical NSAIDs) 51
Blood cell dyscrasia (agranulocytosis, thrombocytopenia and anemia) to non-cytostatic drugs  276
Metabolic reactions from neuroleptics and antidepressants (mainly weight gain) 53
Hyponatremia/SIADH due to antidepressants and antiepileptics 38
CNS toxicity and neuropsychiatric reactions from antiviral therapy and antibiotics 93
Stevens-Johnson syndrome/Toxic epidermal necrolysis 64
Tendon-rupture from flouroquinolones 27
Liver toxicity 462
Rhabdomyolysis related to statins/fibrates 52
Torsade de Pointes/QT-prolongation 23
Narcolepsy associated with Pandemrix 83
Pancreatitis 90
Alopecia 28
Bleedings from new oral anticoagulants (NOACs) 101
Lack of efficacy of NOACs 31
Pneumonitis 23
Renal toxicity 73
Controls 580
Total number of cases 3341

ACE = angiotensin converting enzyme; NSAID = non-steroidal anti-inflammatory drug; NOAC=non-vitamin K oral anticoagulant drug.

Note that the number of cases for a particular ADR may be greater than the total number of cases as some individuals have experienced multiple ADRs concomitantly.