Current status

In March 2024, the below number of individuals have been recruited in Swedegene. DNA and clinical data collection for these are completed.

ADR type Number
Angioedema 549
Anaphylaxis 158
Urticaria 209
Other allergic reactions 122
Cough related to ACE-inhibitors 153
Osteonecrosis and atypical fractures due to bisphosphonates 151
Phototoxic reactions (mainly due to topical NSAIDs) 53
Blood cell dyscrasia (agranulocytosis, thrombocytopenia and anemia) to non-cytostatic drugs  327
Metabolic reactions from neuroleptics and antidepressants (mainly weight gain) 73
Hyponatremia/SIADH due to antidepressants and antiepileptics 39
CNS toxicity and neuropsychiatric reactions from antiviral therapy and antibiotics 97
Stevens-Johnson syndrome/Toxic epidermal necrolysis 69
Tendon-rupture from flouroquinolones 34
Liver toxicity 530
Rhabdomyolysis related to statins/fibrates 57
Torsade de Pointes/QT-prolongation 35
Narcolepsy associated with Pandemrix 85
Hypersomnia associated with Pandemrix 14
Pancreatitis 102
Alopecia 28
Bleedings from new oral anticoagulants (NOACs) 169
Lack of efficacy of NOACs 33
Pneumonitis 47
Renal toxicity 109
Ankle oedema from calcium channel blockers 54
Gingival hyperplasia from calcium channel blockers 17
Adverse reactions to Covid-19 vaccines 931
Thyroiditis 17
Gastrointestinal reactions to medication for Parkinson’s disease 2
Controls 590
Total number of cases 4565

ACE = angiotensin converting enzyme; NSAID = non-steroidal anti-inflammatory drug; NOAC=non-vitamin K oral anticoagulant drug.

Note that the number of cases for a particular ADR may be greater than the total number of cases as some individuals have experienced multiple ADRs concomitantly.