Current status

As of July 1, 2019, the below number of individuals have been recruited in Swedegene. DNA and clinical data collection for these are completed.

ADR type Number
Angioedema 514
Anaphylaxis 112
Urticaria 152
Other allergic reactions 51
Cough related to ACE-inhibitors 152
Osteonecrosis and atypical fractures due to bisphosphonates 119
Phototoxic reactions (mainly due to topical NSAIDs) 50
Blood cell dyscrasia (agranulocytosis, thrombocytopenia and anemia) to non-cytostatic drugs  270
Metabolic reactions from neuroleptics and antidepressants (mainly weight gain) 46
Hyponatremia/SIADH due to antidepressants and antiepileptics 35
CNS toxicity and neuropsychiatric reactions from antiviral therapy and antibiotics 94
Stevens-Johnson syndrome/Toxic epidermal necrolysis 63
Tendon-rupture from flouroquinolones 25
Liver toxicity 461
Rhabdomyolysis related to statins/fibrates 51
Torsade de Pointes/QT-prolongation 22
Narcolepsy associated with Pandemrix 83
Pancreatitis 82
Alopecia 28
Bleedings from new oral anticoagulants (NOACs) 60
Pneumonitis 20
Renal toxicity 70
Controls 580
Total number of cases 3140

ACE = angiotensin converting enzyme; NSAID = non-steroidal anti-inflammatory drug; NOAC=non-vitamin K oral anticoagulant drug.

Note that the number of cases for a particular ADR may be greater than the total number of cases as some individuals have experienced multiple ADRs concomitantly.